Pub. Date : 2022 Feb
PMID : 34998092
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We aimed to assess the tolerability and effectiveness of anti-EGFR immunoliposomes loaded with doxorubicin (anti-EGFR ILs-dox) in glioblastoma multiforme patients. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 2 | We aimed to assess the tolerability and effectiveness of anti-EGFR immunoliposomes loaded with doxorubicin (anti-EGFR ILs-dox) in glioblastoma multiforme patients. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 3 | We aimed to assess the tolerability and effectiveness of anti-EGFR immunoliposomes loaded with doxorubicin (anti-EGFR ILs-dox) in glioblastoma multiforme patients. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 4 | We aimed to assess the tolerability and effectiveness of anti-EGFR immunoliposomes loaded with doxorubicin (anti-EGFR ILs-dox) in glioblastoma multiforme patients. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 5 | In addition, we also treated three patients with anti-EGFR ILs-dox before resection of their relapsed glioblastoma. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 6 | RESULTS: There were no or negligible levels of doxorubicin found in the CSF demonstrating that anti-EGFR ILs-dox are not able to cross the blood-brain barrier (BBB). | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 7 | CONCLUSIONS: We clearly demonstrate that anti-EGFR-immunoliposomes can be targeted to EGFR-amplified glioblastoma and cargo-in this case doxorubicin-can be delivered, although these immunoliposomes do not cross the intact BBB. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |
| 8 | CONCLUSIONS: We clearly demonstrate that anti-EGFR-immunoliposomes can be targeted to EGFR-amplified glioblastoma and cargo-in this case doxorubicin-can be delivered, although these immunoliposomes do not cross the intact BBB. | Doxorubicin | epidermal growth factor receptor | Homo sapiens |