Pub. Date : 2022 Jan 5
PMID : 34986886
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 2 | METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 3 | METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 4 | METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 5 | Mechanistically, dysregulated cellular lipid homeostasis by adiponectin was induced by two concerted actions: 1) suppression of fatty acid synthesis (FAS) through downregulation of SREBP-1 and FAS-related enzymes, and 2) stimulation of lipophagy-mediated lipolysis and FAO. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 6 | Finally, fatty acid metabolic remodeling by adiponectin and the key role of SIRT-1 were confirmed in nude mice bearing breast tumor xenografts. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 7 | CONCLUSION: This study elucidates the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |