PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34986886-0 2022 Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming. Fatty Acids 50-60 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 39-49 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 127-137 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-5 2022 METHODS: The effects of adiponectin on fatty acid metabolism were evaluated by measuring the cellular neutral lipid pool, free fatty acid level, and fatty acid oxidation (FAO). Fatty Acids 149-159 adiponectin, C1Q and collagen domain containing Mus musculus 24-35 34986886-14 2022 Mechanistically, dysregulated cellular lipid homeostasis by adiponectin was induced by two concerted actions: 1) suppression of fatty acid synthesis (FAS) through downregulation of SREBP-1 and FAS-related enzymes, and 2) stimulation of lipophagy-mediated lipolysis and FAO. Fatty Acids 128-138 adiponectin, C1Q and collagen domain containing Mus musculus 60-71 34986886-16 2022 Finally, fatty acid metabolic remodeling by adiponectin and the key role of SIRT-1 were confirmed in nude mice bearing breast tumor xenografts. Fatty Acids 9-19 adiponectin, C1Q and collagen domain containing Mus musculus 44-55 34986886-17 2022 CONCLUSION: This study elucidates the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer. Fatty Acids 80-90 adiponectin, C1Q and collagen domain containing Mus musculus 59-70