Pub. Date : 1987 Aug
PMID : 3497460
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cimetidine and ranitidine increase interleukin-2 production. | Cimetidine | interleukin 2 | Mus musculus |
| 2 | The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. | Cimetidine | interleukin 2 | Mus musculus |
| 3 | The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. | Cimetidine | interleukin 2 | Mus musculus |
| 4 | Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared with media controls of 1 U. | Cimetidine | interleukin 2 | Mus musculus |
| 5 | Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared with media controls of 1 U. | Cimetidine | interleukin 2 | Mus musculus |
| 6 | These data suggest that our previously demonstrated immunofacilitation of proliferative and cytotoxic lymphocyte responses by cimetidine was probably mediated by the presence of increased IL-2. | Cimetidine | interleukin 2 | Mus musculus |