Title : CREB/Sp1-mediated MCL1 expression and NFκB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells.

Pub. Date : 2022 Jan 15

PMID : 34963561






2 Functional Relationships(s)
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1 In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK. Daunorubicin mitogen-activated protein kinase 1 Homo sapiens
2 Cumulatively, our data indicate that DNR induces MCL1 downregulation in K562 cells by promoting p38 MAPK-mediated dephosphorylation of CREB and inhibiting the Akt-ERK axis-mediated Sp1 protein stabilization. Daunorubicin mitogen-activated protein kinase 1 Homo sapiens