Pub. Date : 2021 Dec 2
PMID : 34959345
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Previous studies have shown that certain polyphenols interact with human Pgp. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | We tested the effect of 15 polyphenols of sour cherry origin on the basal and verapamil-stimulated ATPase activity of Pgp, calcein-AM and daunorubicin transport as well as on the conformation of Pgp using the conformation sensitive UIC2 mAb. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Generally, our data demonstrate diverse interactions of the tested polyphenols with Pgp. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Our results also call attention to the potential risks of drug-drug interactions (DDIs) associated with the consumption of dietary polyphenols concurrently with chemotherapy treatment involving Pgp substrate/inhibitor drugs. | Polyphenols | ATP binding cassette subfamily B member 1 | Homo sapiens |