Title : A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS-114.

Pub. Date : 2022 May

PMID : 34951129






1 Functional Relationships(s)
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1 Plasma concentrations of TAS-114 from 185 subjects and those of the endogenous DPD substrate uracil from 24 subjects were used. Uracil dihydropyrimidine dehydrogenase Homo sapiens