Pub. Date : 2021 Dec 17
PMID : 34948342
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test whether activation of MMP-9 causes EE barrier dysfunction, we hypothesized that if that were the case then treatment with hydroxychloroquine (HCQ) could, in fact, inhibit MMP-9, and thus preserve the EE barrier/juxtacrine signaling, and synchronous endothelial-myocyte coupling. | Hydroxychloroquine | matrix metallopeptidase 9 | Homo sapiens |
| 2 | To test whether activation of MMP-9 causes EE barrier dysfunction, we hypothesized that if that were the case then treatment with hydroxychloroquine (HCQ) could, in fact, inhibit MMP-9, and thus preserve the EE barrier/juxtacrine signaling, and synchronous endothelial-myocyte coupling. | Hydroxychloroquine | matrix metallopeptidase 9 | Homo sapiens |
| 3 | Results suggest that MMP-9 activation, endocardial endothelial leakage, endothelial-myocyte (E-M) uncoupling, dyssynchronous mitochondrial fusion-fission (Mfn2/Drp1 ratio), and mito-myocyte uncoupling in the AVF heart failure were found to be rampant; however, treatment with HCQ successfully mitigated some of the deleterious cardiac alterations during CHF. | Hydroxychloroquine | matrix metallopeptidase 9 | Homo sapiens |