Title : (-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A.

Pub. Date : 2021 Dec 8

PMID : 34944489






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant. Polyphenols nuclear factor kappa B subunit 1 Homo sapiens