Title : Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.

Pub. Date : 2022 Mar

PMID : 34937801






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Idasanutlin is a potent inhibitor of the p53-MDM2 interaction that enables re-activation of the p53 pathway which induces cell cycle arrest and/or apoptosis in tumor cells expressing functional p53. RG7388 MDM2 proto-oncogene Homo sapiens