Pub. Date : 2022 Feb
PMID : 34929169
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Biochemical experiments corroborated the simulation results, showing that heparin inhibits the furin-mediated cleavage of spike by binding to the S1/S2 site. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | In simulations of the closed spike homotrimer, heparin binds the RBD and the N-terminal domain of two adjacent spike subunits and hinders opening. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
3 | In simulations of the closed spike homotrimer, heparin binds the RBD and the N-terminal domain of two adjacent spike subunits and hinders opening. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
4 | In simulations of open spike conformations, heparin induces stabilization of the hinge region and a change in RBD motion. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
5 | Taken together, our results indicate that heparin can inhibit SARS-CoV-2 infection by three mechanisms: by allosterically hindering binding to the host cell receptor, by directly competing with binding to host heparan sulfate proteoglycan co-receptors, and by preventing spike cleavage by furin. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |