PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34929169-4	2022	Biochemical experiments corroborated the simulation results, showing that heparin inhibits the furin-mediated cleavage of spike by binding to the S1/S2 site.	Heparin	74-81	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	122-127	
34929169-6	2022	In simulations of the closed spike homotrimer, heparin binds the RBD and the N-terminal domain of two adjacent spike subunits and hinders opening.	Heparin	47-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	29-34	
34929169-6	2022	In simulations of the closed spike homotrimer, heparin binds the RBD and the N-terminal domain of two adjacent spike subunits and hinders opening.	Heparin	47-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	111-116	
34929169-7	2022	In simulations of open spike conformations, heparin induces stabilization of the hinge region and a change in RBD motion.	Heparin	44-51	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	23-28	
34929169-8	2022	Taken together, our results indicate that heparin can inhibit SARS-CoV-2 infection by three mechanisms: by allosterically hindering binding to the host cell receptor, by directly competing with binding to host heparan sulfate proteoglycan co-receptors, and by preventing spike cleavage by furin.	Heparin	42-49	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	271-276