Title : Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Pub. Date : 2022 Jan 15

PMID : 34920170






1 Functional Relationships(s)
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1 We faced this challenge with a 3,4,5,6-tetrahydropyridine-2-amine scaffold harboring an amidine, a key structural component of potential inhibitors of BACE1, the rate-limiting enzyme in the production of Abeta species that make up amyloid plaques in Alzheimer"s disease. 3,4,5,6-tetrahydropyridine-2-amine beta-secretase 1 Homo sapiens