Pub. Date : 2021
PMID : 34912339
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Btk and related kinases (like Tec) are expressed in non-leukemic hematopoietic cells and can be targeted by ibrutinib. | ibrutinib | tec protein tyrosine kinase | Homo sapiens |
| 2 | In respect of intracellular signaling, bacteria induced Btk and Tec phosphorylation in both CLL and control platelets that was inhibited by ibrutinib. | ibrutinib | tec protein tyrosine kinase | Homo sapiens |
| 3 | Our data suggest that ibrutinib impairment of FcgammaRIIA-mediated platelet activation by bacteria results from a combination of Btk and Tec inhibition, although off-target effects on additional kinases cannot be discarded. | ibrutinib | tec protein tyrosine kinase | Homo sapiens |