PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34912339-2 2021 Btk and related kinases (like Tec) are expressed in non-leukemic hematopoietic cells and can be targeted by ibrutinib. ibrutinib 108-117 tec protein tyrosine kinase Homo sapiens 30-33 34912339-10 2021 In respect of intracellular signaling, bacteria induced Btk and Tec phosphorylation in both CLL and control platelets that was inhibited by ibrutinib. ibrutinib 140-149 tec protein tyrosine kinase Homo sapiens 64-67 34912339-12 2021 Our data suggest that ibrutinib impairment of FcgammaRIIA-mediated platelet activation by bacteria results from a combination of Btk and Tec inhibition, although off-target effects on additional kinases cannot be discarded. ibrutinib 22-31 tec protein tyrosine kinase Homo sapiens 137-140