Title : WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.

Pub. Date : 2021 Dec 15

PMID : 34907909






1 Functional Relationships(s)
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1 Mechanistically, we found that AMPKalpha2 was ubiquitinated and, in turn, inhibited in its activatory phosphorylation by WWP1, whereas WWP1 inhibition facilitated AMPKalpha2 activity in the muscle to compensate for the reduction in glucose uptake observed upon PI3K inhibition. Glucose protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens