Pub. Date : 2021 Dec
PMID : 34907738
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of NF-kappaB using inhibitor Bay 11-7085 repressed proliferation, survival, migration, and invasion but increased apoptosis in 143B and MG63 OS cells, indicating that NF-kappaB is critically implicated in the oncogenesis of OS. | BAY 11-7085 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Inhibition of NF-kappaB using inhibitor Bay 11-7085 repressed proliferation, survival, migration, and invasion but increased apoptosis in 143B and MG63 OS cells, indicating that NF-kappaB is critically implicated in the oncogenesis of OS. | BAY 11-7085 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Notably, Bay 11-7085 not only inactivated NF-kappaB but also reduced the phosphorylation of AKT via its induction of PTEN, suggesting the existence of a novel NF-kappaB/PTEN/PI3K/AKT axis. | BAY 11-7085 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Notably, Bay 11-7085 not only inactivated NF-kappaB but also reduced the phosphorylation of AKT via its induction of PTEN, suggesting the existence of a novel NF-kappaB/PTEN/PI3K/AKT axis. | BAY 11-7085 | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | In vivo, Bay 11-7085 suppressed tumor growth in the bone by targeting NF-kappaB and AKT. | BAY 11-7085 | nuclear factor kappa B subunit 1 | Homo sapiens |