Pub. Date : 2022 Jan
PMID : 34902447
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid ameliorates amyloid beta-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 2 | RESULTS: In our study, ursolic acid successfully repressed amyloid beta-induced paralysis and hypersensitivity to serotonin in Caenorhabditis elegans. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 3 | The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 4 | The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 5 | The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 6 | CONCLUSIONS: Our study revealed that ursolic acid prevented amyloid beta-induced proteotoxic stress, specifically by reducing the amount of amyloid beta and increasing proteasome activity in vivo. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 7 | CONCLUSIONS: Our study revealed that ursolic acid prevented amyloid beta-induced proteotoxic stress, specifically by reducing the amount of amyloid beta and increasing proteasome activity in vivo. | ursolic acid | amyloid beta precursor protein | Homo sapiens |
| 8 | Furthermore, the therapeutic effect of ursolic acid on transgenic nematodes expressing amyloid beta depended on the increased activity of the proteasome. | ursolic acid | amyloid beta precursor protein | Homo sapiens |