Title : Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way.

Pub. Date : 2021 Dec 11

PMID : 34895136






2 Functional Relationships(s)
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Protein Name
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1 Many studies showed that metformin exerted beneficial effects on multiple cardiovascular diseases by mediating multiple proteins such as AMPK, NF-kappaB, and AKT. Metformin nuclear factor kappa B subunit 1 Homo sapiens
2 AMPK activation and NF-kappaB inhibition could inhibit AVICs calcification induced by PM treatment; however, AMPK and AKT inhibition reversed the protective effect of metformin. Metformin nuclear factor kappa B subunit 1 Homo sapiens