Title : Glutathione synthesis primes monocytes metabolic and epigenetic pathway for β-glucan-trained immunity.

Pub. Date : 2021 Dec 7

PMID : 34894475






1 Functional Relationships(s)
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1 Gclc deficiency compromised the activation of mammalian target of rapamycin-1 (mTOR) and expression of c-Myc transcription factors, abrogating the energy utilization and the metabolic reprogramming that allows beta-glucan-trained macrophages to switch to glycolysis and glutaminolysis. beta-Glucans MYC proto-oncogene, bHLH transcription factor Homo sapiens