Pub. Date : 2021
PMID : 34873461
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Triptolide was used to evaluate its specific treatment effects on METTL3 in OSCC cells. | triptolide | methyltransferase like 3 | Mus musculus |
| 2 | Triptolide inhibited METTL3-mediated SLC7A11 expression, thus suppressing malignancy of OSCC cells. | triptolide | methyltransferase like 3 | Mus musculus |
| 3 | In conclusion, the new finding of the manuscript is that METTL3 enhances the mRNA stability of SLC7A11 via m6A-mediated binding of IGF2BP2, which thus promotes OSCC progression, and triptolide inhibits OSCC by suppressing METTL3-SLC7A11 axis. | triptolide | methyltransferase like 3 | Mus musculus |
| 4 | Triptolide has a potential to be as an effective anti-OSCC drug targeted to METTL3. | triptolide | methyltransferase like 3 | Mus musculus |