Pub. Date : 2022 Jan 1
PMID : 34871844
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthesis and biological evaluation of novel PET tracers (18F)AG120 & (18F)AG135 for imaging mutant isocitrate dehydrogenase 1 expression. | ivosidenib | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Furthermore, (18F)AG120 micro-PET/CT imaging displayed significantly greater uptake in IDH1-mutant than in wild-type tumors, Relatively, uptake of (18F)AG135 was observed neither in IDH1-mutant tumor xenografts nor in wild-type tumors. | ivosidenib | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | This study suggests that (18F)AG120 is a promising radiotracer for PET imaging of IDH1 mutation, However, further optimization and investigation are necessary for (18F)AG135 due to the limited uptake in mutated IDH1-expressing tumors. | ivosidenib | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |