Pub. Date : 1986 Apr 24
PMID : 3487052
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Conversion of MPTP to 1-methyl-4-phenylpyridine (MPP+) by monoamine oxidase-B (MAO-B) appears necessary for this neurotoxicity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Rattus norvegicus |
2 | Conversion of MPTP to 1-methyl-4-phenylpyridine (MPP+) by monoamine oxidase-B (MAO-B) appears necessary for this neurotoxicity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Rattus norvegicus |
3 | It is proposed that the conversion of MPTP to MPP+ occurs via MAO-B within serotonin and histamine neurons which may innervate the substantia nigra where the toxin MPP+ could be released and then taken up into the dopamine neurons. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Rattus norvegicus |