Pub. Date : 2022 Feb
PMID : 34854520
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valosin-containing protein (VCP), a suppressor of cardiac hypertrophy via inhibiting mechanistic target of rapamycin (mTOR) signaling, was validated as a target of miR-339-5p. | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 2 | Valosin-containing protein (VCP), a suppressor of cardiac hypertrophy via inhibiting mechanistic target of rapamycin (mTOR) signaling, was validated as a target of miR-339-5p. | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 3 | MiR-339-5p suppressed VCP protein expression, leading to elevated phosphorylation of mTOR and ribosomal protein S6 kinase (S6K). | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 4 | VCP depletion activated the mTOR/S6K cascade and could compromise the anti-hypertrophic effects of miR-339-5p inhibitor. | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 5 | Additionally, the hypertrophic responses caused by miR-339-5p was alleviated in the presence of mTOR inhibitor rapamycin. | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 6 | In conclusion, our research revealed that miR-339-5p promoted ISO-induced cardiomyocyte hypertrophy by targeting VCP to activate the mTOR signaling, suggesting a promising therapeutic intervention by interfering miR-339-5p. | mir-339-5p | mechanistic target of rapamycin kinase | Rattus norvegicus |