Title : Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones.

Pub. Date : 2021 Nov 6

PMID : 34832913






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The best inhibitors described so far (leptomycin B and SINE compounds) interact with XPO1 through a covalent interaction with Cys528 located in the NES-binding cleft of XPO1. leptomycin B exportin 1 Homo sapiens
2 The best inhibitors described so far (leptomycin B and SINE compounds) interact with XPO1 through a covalent interaction with Cys528 located in the NES-binding cleft of XPO1. leptomycin B exportin 1 Homo sapiens