Pub. Date : 2022 Feb
PMID : 34823857
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We further measured the inhibitory activity of 5 compounds (rifapentine, velpatasvir, glecaprevir, anidulafungin, and FAD disodium) on SARS-CoV-2 PLpro using Ubiquitin-Rhodamine 110 Gly fluorescent intensity assay. | rifapentine | ORF1a polyprotein;ORF1ab polyprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | The highest inhibition of PLpro activity was seen with rifapentine (IC50: 15.18 muM) and FAD disodium (IC50: 12.39 muM), the drugs with high predicted KIBA scores and binding affinities. | rifapentine | ORF1a polyprotein;ORF1ab polyprotein | Severe acute respiratory syndrome coronavirus 2 |