Protein Name ORF1a polyprotein;ORF1ab polyprotein
Organism Severe acute respiratory syndrome coronavirus 2
Gene ID 43740578
Gene Symbol


UniProt P0DTD1 (R1AB_SARS2), P0DTC1 (R1A_SARS2)
Relationships Total Number of functionally related compound(s) : 487
Total Number of Articles : 397

ORF1a polyprotein;ORF1ab polyprotein

Gene Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

  • ORF1a polyprotein;ORF1ab polyprotein
  • 2'-O-ribose methyltransferase
  • 3'-to-5' exonuclease
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