Title : PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway.

Pub. Date : 2022 Mar

PMID : 34816327






1 Functional Relationships(s)
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1 Our findings clearly confirmed that the p. H1047R and p. H1047L mutants could reduce the inhibitory effect of DeltaNp63alpha on the kinase domain of PIK3CA, resulting in increased activity of PI3K downstream signals. deltanp63alpha phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens