Pub. Date : 2022 Apr
PMID : 34811646
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Excess branched-chain amino acids alter myotube metabolism and substrate preference which is worsened by concurrent insulin resistance. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 2 | PURPOSE: Branched-chain amino acids (BCAA) have been shown to enhance several cellular signaling pathways including protein synthesis and mitochondrial biogenesis, yet population data demonstrate a correlation between circulating BCAA and severity of insulin resistance which has been hypothesized to be, in part, a byproduct of BCAA inhibition of mitochondrial function. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 3 | PURPOSE: Branched-chain amino acids (BCAA) have been shown to enhance several cellular signaling pathways including protein synthesis and mitochondrial biogenesis, yet population data demonstrate a correlation between circulating BCAA and severity of insulin resistance which has been hypothesized to be, in part, a byproduct of BCAA inhibition of mitochondrial function. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 4 | PURPOSE: Branched-chain amino acids (BCAA) have been shown to enhance several cellular signaling pathways including protein synthesis and mitochondrial biogenesis, yet population data demonstrate a correlation between circulating BCAA and severity of insulin resistance which has been hypothesized to be, in part, a byproduct of BCAA inhibition of mitochondrial function. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 5 | PURPOSE: Branched-chain amino acids (BCAA) have been shown to enhance several cellular signaling pathways including protein synthesis and mitochondrial biogenesis, yet population data demonstrate a correlation between circulating BCAA and severity of insulin resistance which has been hypothesized to be, in part, a byproduct of BCAA inhibition of mitochondrial function. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 6 | In addition, insulin-resistant cells treated with 20 mM BCAA exhibited reduced gene expression of Ppargc1a, Cytc, Atp5b, Glut4, and several glycolytic enzymes versus insulin sensitive cells treated with 20 mM BCAA. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 7 | In addition, insulin-resistant cells treated with 20 mM BCAA exhibited reduced gene expression of Ppargc1a, Cytc, Atp5b, Glut4, and several glycolytic enzymes versus insulin sensitive cells treated with 20 mM BCAA. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 8 | In addition, insulin-resistant cells treated with 20 mM BCAA exhibited reduced gene expression of Ppargc1a, Cytc, Atp5b, Glut4, and several glycolytic enzymes versus insulin sensitive cells treated with 20 mM BCAA. | Amino Acids, Branched-Chain | insulin | Homo sapiens |
| 9 | CONCLUSIONS: Collectively, these findings suggest BCAA at supraphysiologically high levels may negatively alter mitochondrial metabolism, and concurrent insulin resistance may also diminish peak mitochondrial capacity, as well as impede molecular adaptations that support a transition to a glycolytic preference/compensation. | Amino Acids, Branched-Chain | insulin | Homo sapiens |