Title : Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets.

Pub. Date : 2021

PMID : 34803706






3 Functional Relationships(s)
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1 Lorcaserin can restrain patients" appetite and improve insulin sensitivity and hyperinsulinemia mainly through activating 5-HT2CR in the hypothalamus. lorcaserin insulin Homo sapiens
2 Lorcaserin did not change insulin synthesis ATP content, but lorcaserin decrease cytosolic free calcium level ((Ca2+)i) in MIN6 cells stimulated with glucose and also inhibit insulin secretion and (Ca2+)i in MIN6 treated with potassium chloride. lorcaserin insulin Homo sapiens
3 Lorcaserin did not change insulin synthesis ATP content, but lorcaserin decrease cytosolic free calcium level ((Ca2+)i) in MIN6 cells stimulated with glucose and also inhibit insulin secretion and (Ca2+)i in MIN6 treated with potassium chloride. lorcaserin insulin Homo sapiens