Title : Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma.

Pub. Date : 2021

PMID : 34790119






1 Functional Relationships(s)
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1 SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment. Serine protein tyrosine phosphatase non-receptor type 11 Homo sapiens