Pub. Date : 2021
PMID : 34790098
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions. | Calcium | cyclin dependent kinase 5 | Homo sapiens |
| 2 | Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. | Calcium | cyclin dependent kinase 5 | Homo sapiens |
| 3 | However, how CDK5-targeted astrocytes affect calcium regulation and whether this phenomenon is associated with changes in neuronal plasticity have not yet been analyzed. | Calcium | cyclin dependent kinase 5 | Homo sapiens |
| 4 | In this study, CDK5 KD astrocytes transplanted in CA3 remained at the injection site without proliferation, regulated calcium in the CA1 hippocampal region after excitotoxicity by glutamate in ex vivo hippocampal slices, improving synapsin and PSD95 clustering. | Calcium | cyclin dependent kinase 5 | Homo sapiens |
| 5 | Also, these effects were supported by CDK5 inhibition (CDK5i) in vitro through intracellular stabilization of calcium levels in astrocytes. | Calcium | cyclin dependent kinase 5 | Homo sapiens |
| 6 | In summary, induction of calcium homeostasis at the CA1 hippocampal area by CDK5 KD astrocytes transplanted in the CA3 area highlights the role of astrocytes as a cell therapy target due to CDK5-KD astrocyte-mediated synaptic clustering, calcium spreading regulation between both areas, and recovery of the intracellular astrocyte-neuron calcium imbalance and plasticity impairment generated by glutamate excitotoxicity. | Calcium | cyclin dependent kinase 5 | Homo sapiens |