CPRiL

CDK5

cyclin dependent kinase 5

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

• cyclin-dependent kinase 5
• TPKII catalytic subunit
• cell division protein kinase 5
cyclin-dependent-like kinase 5
epididymis secretory sperm binding protein
protein kinase CDK5 splicing
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
LIS7
PSSALRE