Pub. Date : 2022 Feb
PMID : 34785538
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that SPTLC2, a subunit of the serine palmitoyltransferase (SPT) complex, catalyzing the first step in de novo sphingolipid synthesis, localizes dually to the ER and the outer mitochondrial membrane. | Sphingolipids | serine palmitoyltransferase long chain base subunit 2 | Homo sapiens |
| 2 | Loss of SPTLC2 prevents the synthesis of mitochondrial sphingolipids and protects from palmitate-induced mitochondrial toxicity, a process dependent on mitochondrial ceramides. | Sphingolipids | serine palmitoyltransferase long chain base subunit 2 | Homo sapiens |