Pub. Date : 2022 Apr
PMID : 34783031
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we orally treated SOD1G93A mice with Trimetazidine, solubilized in drinking water at a dose of 20 mg/kg, from disease onset. | Trimetazidine | superoxide dismutase 1, soluble | Mus musculus |
| 2 | KEY RESULTS: Trimetazidine administration delays motor function decline, improves muscle performance and metabolism, and significantly extends overall survival of SOD1G93A mice (increased median survival of 16 days and 12.5 days for male and female respectively). | Trimetazidine | superoxide dismutase 1, soluble | Mus musculus |
| 3 | CONCLUSION AND IMPLICATIONS: In SOD1G93A mice, therapeutic effect of Trimetazidine is underpinned by its action on mitochondrial function in skeletal muscle and spinal cord. | Trimetazidine | superoxide dismutase 1, soluble | Mus musculus |