Title : Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring.

Pub. Date : 2021 Nov 26

PMID : 34779863






2 Functional Relationships(s)
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1 Both the mRNA and protein expression of GRK4 and its downstream target AT1R were increased in offspring of PM2.5-exposed paternal rats, which was reflected in its function because treatment with losartan, an AT1R antagonist, decreased the blood pressure and increased urine volume and sodium excretion. Losartan angiotensin II receptor, type 1a Rattus norvegicus
2 Both the mRNA and protein expression of GRK4 and its downstream target AT1R were increased in offspring of PM2.5-exposed paternal rats, which was reflected in its function because treatment with losartan, an AT1R antagonist, decreased the blood pressure and increased urine volume and sodium excretion. Losartan angiotensin II receptor, type 1a Rattus norvegicus