Title : Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation.

Pub. Date : 2022 Jan 1

PMID : 34774714






1 Functional Relationships(s)
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1 Chronic morphine treatments for 7 days reduced the protein expression of MKP-1 and MKP-3 in the spinal cord and increased the phosphorylation of p38, ERK1/2 and the level of proinflammatory mediator, such as IL-1beta, IL-6 and TNF-alpha. Morphine interleukin 6 Homo sapiens