Pub. Date : 2021 Nov 25
PMID : 34762427
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 2 | hFGF1, which is associated with low stability in vivo, is known to be stabilized by binding heparin sulfate, a glycosaminoglycan that aids the protein in the activation of its cell surface receptor. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 3 | The poor thermal and proteolytic stability of hFGF1 and the stabilizing role of heparin have long been observed experimentally; however, the mechanistic details of these phenomena are not well understood. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 4 | We have observed a conformational change in the heparin-binding pocket of hFGF1 that occurs only in the absence of heparin. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 5 | We have observed a conformational change in the heparin-binding pocket of hFGF1 that occurs only in the absence of heparin. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 6 | Several intramolecular interactions were also identified within the heparin-binding pocket that form only when hFGF1 interacts with heparin. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 7 | Several intramolecular interactions were also identified within the heparin-binding pocket that form only when hFGF1 interacts with heparin. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 8 | This conformational transition results in increased flexibility of the heparin-binding pocket and provides an explanation for the susceptibility of apo hFGF1 to proteolytic degradation and thermal instability. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 9 | This study provides a glimpse into mechanistic details of the heparin-mediated stabilization of hFGF1 and encourages the use of microsecond-level MD in studying the effect of binding on protein structure and dynamics. | Heparin | fibroblast growth factor 1 | Homo sapiens |
| 10 | In addition, the observed differential behavior of hFGF1 in the absence and presence of heparin provides an example, where microsecond-level all-atom MD simulations are necessary to see functionally relevant biomolecular phenomena that otherwise will not be observed on sub-microsecond time scales. | Heparin | fibroblast growth factor 1 | Homo sapiens |