Pub. Date : 2021 Nov 10
PMID : 34758851
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3beta/Nrf2. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Co-immunoprecipitation (Co-IP) results indicated that curcumin is a potent Keap1 Kelch domain-dependent Nrf2 activator that stabilizes Nrf2 by hindering its ubiquitination. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Co-immunoprecipitation (Co-IP) results indicated that curcumin is a potent Keap1 Kelch domain-dependent Nrf2 activator that stabilizes Nrf2 by hindering its ubiquitination. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | The increased activation of Nrf2 and its target antioxidant genes by curcumin could significantly decrease As3+-generated ROS. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Knockdown of Nrf2 abolished curcumin-induced autophagy and downregulated ROS. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | These results demonstrated that curcumin prevents As3+-induced cell transformation by inducing autophagy via the activation of the Nrf2 signaling pathway in BEAS-2B cells. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 7 | Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 8 | Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 9 | Further studies showed that curcumin decreased the Nrf2 level in AsT by activating GSK-3beta to inhibit the activation of PI3K/AKT. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 10 | Co-IP assay results showed that curcumin promoted the interaction of Nrf2 with the GSK-3beta/beta-TrCP axis and ubiquitin. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 11 | Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 12 | Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 13 | Furthermore, in vitro and in vivo results showed that curcumin induced cell apoptosis, and had anti-angiogenesis and anti-tumorigenesis effects as a result of activating the GSK-3beta/beta-TrCP ubiquitination pathway and subsequent decrease in Nrf2. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 14 | CONCLUSIONS: Taken together, in the first stage, curcumin activated Nrf2, decreased ROS, and induced autophagy in normal cells to prevent As3+-induced cell transformation. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 15 | In the second stage, curcumin promoted ROS and apoptosis and inhibited angiogenesis via inhibition of constitutive expression of Nrf2 in AsT to prevent tumorigenesis. | Curcumin | NFE2 like bZIP transcription factor 2 | Homo sapiens |