Title : Insulin smart drug delivery nanoparticles of aminophenylboronic acid-POSS molecule at neutral pH.

Pub. Date : 2021 Nov 8

PMID : 34750459






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1 Insulin smart drug delivery nanoparticles of aminophenylboronic acid-POSS molecule at neutral pH. 3-aminobenzeneboronic acid insulin Homo sapiens
2 Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3-aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency: 73.2%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. 3-aminobenzeneboronic acid insulin Homo sapiens
3 Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3-aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency: 73.2%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. 3-aminobenzeneboronic acid insulin Homo sapiens
4 Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3-aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency: 73.2%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. 3-aminobenzeneboronic acid insulin Homo sapiens
5 Here, a glucose-responsive continuous insulin delivery system is developed, where novel polyhedral oligosilsesquioxane (POSS) modified with 3-aminophenylboronic acid (APBA) were used to encapsulate insulin (insulin entrapment efficiency: 73.2%) to prepare a fast response, high stability, good distribution, and excellent biocompatible system. 3-aminobenzeneboronic acid insulin Homo sapiens
6 Due to the strong hydrophobicity of POSS, the POSS moiety is located at the core in aqueous solution and combines with the boronic group of APBA and the diol generated in PEG-insulin to form a nanomicelle structure, that is, nanoparticles naturally. 3-aminobenzeneboronic acid insulin Homo sapiens
7 Circular dichroism (CD) spectroscopy analysis was performed to measure insulin activity by comparing secondary structures of insulin, PEG-Insulin, and POSS-APBA@insulin. 3-aminobenzeneboronic acid insulin Homo sapiens
8 Circular dichroism (CD) spectroscopy analysis was performed to measure insulin activity by comparing secondary structures of insulin, PEG-Insulin, and POSS-APBA@insulin. 3-aminobenzeneboronic acid insulin Homo sapiens