Title : Molecular insights into the interaction of 5-fluorouracil and Fe3O4 nanoparticles with beta-casein: An experimental and theoretical study.

Pub. Date : 2022 Feb 15

PMID : 34749259






5 Functional Relationships(s)
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1 We investigated the potential carrier of milk beta-casein (beta-CN) and its interactions with 5-fluorouracil (5-FU) and iron oxide nanoparticles (Fe3O4 NPs). ferryl iron apoptotic chromatin condensation inducer 1 Homo sapiens
2 The fluorescence data indicated both Fe3O4 NPs and 5-FU could quench the intrinsic fluorescence of beta-CN. ferryl iron apoptotic chromatin condensation inducer 1 Homo sapiens
3 Fluorescence measurements showed that the single interaction of beta-CN with 5-FU or Fe3O4 NPs was static, while reacted beta-CN with both 5-FU and Fe3O4 NPs simultaneously showed a dynamic quenching. ferryl iron apoptotic chromatin condensation inducer 1 Homo sapiens
4 Fluorescence measurements showed that the single interaction of beta-CN with 5-FU or Fe3O4 NPs was static, while reacted beta-CN with both 5-FU and Fe3O4 NPs simultaneously showed a dynamic quenching. ferryl iron apoptotic chromatin condensation inducer 1 Homo sapiens
5 The outcomes highlighted that beta-CN protein could form a great bind with 5-FU and Fe3O4 NPs ligands (supporting the zeta potential assay results) by independent binding sites. ferryl iron apoptotic chromatin condensation inducer 1 Homo sapiens