Title : Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling.

Pub. Date : 2021 Nov 29

PMID : 34747418






1 Functional Relationships(s)
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1 The D-gal-induced accelerated aging model in vivo demonstrated that Uro B could elevate the activities of superoxide dismutase, catalase, glutathione peroxidase, and total anti-oxidation capability, decrease malondialdehyde content, regulate the levels of inflammatory cytokines (IL-6, TNF-alpha, IFN-gamma, IL-4, and IL-1beta) in the small intestine, and reshape the composition of gut microbiota and decrease the intestinal barrier injury in aging mice. urolithin B interferon gamma Mus musculus