Title : Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration.

Pub. Date : 2022 Apr

PMID : 34741776






1 Functional Relationships(s)
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1 JAK1/2 and STAT1 inhibitors could reverse the reduction of SLC7A11, GPx4 and GSH expression induced by IFN-gamma, indicating IFN-gamma induces ARPE-19 cell ferroptosis via activation of the JAK1-2/STAT1/SLC7A11 signaling pathway. Glutathione solute carrier family 7 member 11 Homo sapiens