Pub. Date : 2021 Dec 5
PMID : 34736968
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oral administration of niclosamide reduced TAC-induced increase of serum IL-6 in heart failure mice. | Niclosamide | interleukin 6 | Mus musculus |
| 2 | At the concentrations more than 0.1 muM, niclosamide reduced the increased interleukin- 6 (IL-6) mRNA expression in lipopolysaccharide (LPS)-stimulated RAW264.7 and THP-1 derived macrophages. | Niclosamide | interleukin 6 | Mus musculus |
| 3 | At the concentrations more than 0.1 muM, niclosamide reduced the increased interleukin- 6 (IL-6) mRNA expression in lipopolysaccharide (LPS)-stimulated RAW264.7 and THP-1 derived macrophages. | Niclosamide | interleukin 6 | Mus musculus |
| 4 | In cultured primary cardiomyocytes and cardiac fibroblasts, niclosamide (more than 0.1 muM) suppressed IL-6- and phenylephrine-induced cardiomyocyte hypertrophy, and inhibited collagen secretion from cardiac fibroblasts. | Niclosamide | interleukin 6 | Mus musculus |
| 5 | In conclusion, niclosamide attenuates heart failure in mice and the underlying mechanisms include enhancing mitochondrial respiration of cardiomyocytes, inhibiting collagen secretion from cardiac fibroblasts, and reducing the elevated serum inflammatory mediator IL-6. | Niclosamide | interleukin 6 | Mus musculus |