Title : β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins.

Pub. Date : 2021 Dec

PMID : 34736896






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It is also feasible that such structural changes improve synaptic vesicle sequestration of 1-methyl-4-phenylpyridinium (MPP+), a toxic metabolite of MPTP, which would explain why dopaminergic neurons expressing beta-synuclein and lacking alpha-synuclein and/or gamma-synuclein are resistant to this neurotoxin. 1-Methyl-4-phenylpyridinium amyloid beta (A4) precursor protein Mus musculus