Pub. Date : 2021 Oct 19
PMID : 34736121
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | At the molecular level, metformin inhibits an inflammatory program executed by HIF1alpha in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
2 | At the molecular level, metformin inhibits an inflammatory program executed by HIF1alpha in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |