Title : Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.

Pub. Date : 2021 Oct 19

PMID : 34736121






2 Functional Relationships(s)
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1 At the molecular level, metformin inhibits an inflammatory program executed by HIF1alpha in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner. Reactive Oxygen Species hypoxia inducible factor 1 subunit alpha Homo sapiens
2 At the molecular level, metformin inhibits an inflammatory program executed by HIF1alpha in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner. Reactive Oxygen Species hypoxia inducible factor 1 subunit alpha Homo sapiens