Title : Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis.

Pub. Date : 2021 Nov 15

PMID : 34730139






5 Functional Relationships(s)
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1 Mechanistically, in AML-12 and LX-2 cells, PIP evoked Nrf2 nuclear translocation and increased transcriptions of Nrf2-responsive antioxidative genes. piperine NFE2 like bZIP transcription factor 2 Homo sapiens
2 Mechanistically, in AML-12 and LX-2 cells, PIP evoked Nrf2 nuclear translocation and increased transcriptions of Nrf2-responsive antioxidative genes. piperine NFE2 like bZIP transcription factor 2 Homo sapiens
3 Knockdown of Nrf2 abrogated the protective activity of PIP against TGF-beta1. piperine NFE2 like bZIP transcription factor 2 Homo sapiens
4 Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling. piperine NFE2 like bZIP transcription factor 2 Homo sapiens
5 Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling. piperine NFE2 like bZIP transcription factor 2 Homo sapiens