Title : mTOR and ERK1/2 signaling participate in the process of acetate regulating lipid metabolism and HSL expression.

Pub. Date : 2021 Oct 29

PMID : 34727637






2 Functional Relationships(s)
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1 Methods: The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 (ERK1/2) activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively. 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine mechanistic target of rapamycin kinase Homo sapiens
2 Activation of ERK1/2 and mTOR by respective addition in media with ceramide C6 and MHY1485 significantly attenuated decreased lipid deposition and increased HSL expression caused by acetate. 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine mechanistic target of rapamycin kinase Homo sapiens