Pub. Date : 2021 Nov 1
PMID : 34725418
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A-status is associated with blood concentration and dose-requirement of tacrolimus in heart transplant recipients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | High inter-individual variability in tacrolimus clearance is attributed to genetic polymorphisms of CYP3A enzymes. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | However, due to CYP3A phenoconversion induced by non-genetic factors, continuous changes in tacrolimus-metabolizing capacity entail frequent dose-refinement for optimal immunosuppression. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | In low CYP3A4 expressers carrying CYP3A5*3/*3, the dose-corrected tacrolimus level was significantly higher than in normal CYP3A4 expressers or in those with CYP3A5*1. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Modification of the initial tacrolimus dose was required for all patients: dose reduction by 20% for low CYP3A4 expressers, a 40% increase for normal expressers and a 2.4-fold increase for CYP3A5*1 carriers. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Although monitoring of tacrolimus blood concentration cannot be omitted, assaying recipients" CYP3A-status can guide optimization of the initial tacrolimus dose, and can facilitate personalized tacrolimus therapy during steroid withdrawal in the late post-operative period. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |