Title : IL1RAP Pulls a Double Shift in the Cysteine Factory.

Pub. Date : 2021 Nov

PMID : 34725089






2 Functional Relationships(s)
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1 In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884. Cysteine cystathionine gamma-lyase Homo sapiens
2 In this issue of Cancer Discovery, Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine gamma-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.See related article by Zhang et al., p. 2884. Cysteine cystathionine gamma-lyase Homo sapiens